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  • 檢驗醫學

    性激素6項對圍絕經期婦女血脂4項水平的影響

    曹文

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    【摘要】  目的 評價性激素6項對圍絕經期婦女血脂4項水平的影響,了解圍絕經期婦女性激素水平、血脂水平關系,以早期預警動脈粥樣硬化、冠心病、高血壓等血脂異常疾病,確保女性生命安全、健康狀況。方法 選擇我院2019年1~6月收治的圍絕經期婦女,從45~55歲、56~65歲圍絕經期婦女中各選擇120例作為觀察1組與觀察2組。另外,選擇同期25~44歲健康體檢女性120名作為對照組。

    【關鍵字】  圍絕經期,性激素6項,血脂4項,篩查

    中圖分類號:文獻標識碼:文章編號:

    [Abstract] Objective To evaluate the effects of the six sex hormones on the four levels of blood lipids in perimenopausal women, and to understand the relationship between sex hormone levels and blood lipid levels in perimenopausal women, so as to early warn atherosclerosis, coronary heart disease, hypertension and other dyslipidemia diseases, to ensure the safety and health of women. Methods The perimenopausal women who were admitted to our hospital from January to June 2019 were selected, 120 perimenopausal women aged 45-55 and 56-65 were selected as observation group 1 and observation group 2. In addition, 120 healthy women aged 25-44 in the same period were selected as the control group. Three groups of female subjects participated in the informed participation and were reviewed and approved by the ethics committee. All six sex hormones [follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), prolactin (PRL), and testosterone (T), progesterone (P)], four blood lipids [serum total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), low density lipoprotein,(LDL)] level testing, patients with informed consent to participate, and compare the levels of various indicators in the three groups.

    圍絕經期女性的身體狀況明顯有別于其他階段,患者月經以及泌尿生殖道等發生變化。在臨床工作中發現,當前圍絕經期患者的年齡開始呈現明顯的年輕化態勢。分析此情況發生的原因,可能與人們生活壓力以及工作壓力的增大、生活節奏加快等因素有關[1-2]。另外,我國社會人口老齡化趨勢明顯加重,導致老年圍絕經期婦女增多表現[3]。圍絕經期婦女多發性激素水平異常情況明顯,其中,卵泡刺激素(follicle-stimulating hormone,FSH)、促黃體素(luteinizing hormone,LH)、雌二醇(E2)、泌乳素(prolactin,PRL)降低明顯,睪酮(testosterone,T)、孕酮(Progesterone,P)升高明顯,性激素水平波動情況下增加了代謝異常、血脂異常發生風險,進而增加了罹患心血管、肥胖等疾病的風險,故需積極預警干預[4-5]?;诖?,本文就我院收治的圍絕經期婦女以及健康體檢女性為例,研究圍絕經期婦女性激素、血脂水平關系。 1 資料與方法 1.1一般資料 研究對象均為女性,時間選自2019年1~6月,從中選擇45~55歲、56~65歲圍絕經期婦女以及25~44歲健康體檢女性各120例作為觀察1組、觀察2組、對照組。納入標準:①獲得倫理委員會批準。②參與女性知情同意,理解、配合能力正常。③病歷資料完整。排除標準:①凝血功能障礙患者。②重要臟器功能不全患者。③生殖系統疾病患者。④自身免疫性疾病患者。⑤應用影響檢測結果準確性藥物患者。觀察1組:患者年齡45~55歲,平均年齡(50.03±3.50)歲;平均舒張壓為(83.50±6.50)mm Hg,平均收縮壓為(125.05±8.50)mm Hg;平均BMI指數為(24.30±1.50)kg/m2。觀察2組:患者年齡56~65歲,平均年齡(60.05±3.20)歲;平均舒張壓為(86.80±6.80)mm Hg,收縮壓為(130.05±8.50)mm Hg;平均BMI指數為(25.60±1.30)kg/m2。對照組:患者年齡25~44歲,平均年齡(30.05±3.20)歲;平均舒張壓為(76.05±7.50)mm Hg,收縮壓為(118.80±9.50)mm Hg;平均BMI指數為(22.30±1.30)kg/m2。3組受試女性年齡、BMI指數、血壓差異有統計學意義,P<0.05。所有調查對象的臨床資料遞交倫理委員會審核并獲得批準。
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